http://www.medconnect.me/default.aspxThe latest Regional News.Copyright 2005 - 2009 EPMI. All rights reserved.A high level of an enzyme that causes the deacetylation of histones associated with genes important for learning and memory may be a common feature that mediates the cognitive impairment seen in animal models of Alzheimer’s disease and human patients with the disease. Inhibition of this gene,...http://www.medconnect.me/tabid/93/ct1/c11877/Epigenetics-Proposed-as-Mechanism-of-Alzheimer-s-Cognitive-Impairment/Default.aspx02-Apr-2012I was recently in Manila to attend a family function. While there we had quite an interesting experience that began when my brother-in-law, a previously healthy 41-year-old white male of Croatian descent, came to breakfast one morning limping. As we sat in the hotel restaurant chatting over coffee...http://www.medconnect.me/tabid/93/ct1/c11870/Perspective-Gout-Thrilla-in-Manila/Default.aspx30-Mar-2012The process of labor and delivery is considered to be a joyous event in women’s lives, and most of the time it is. However, practitioners have to be aware of potential complications that can have dire adverse outcomes, causing maternal morbidity and mortality as well as severe consequences for the...http://www.medconnect.me/tabid/93/ct1/c11871/Commentary-The-Unexpectedly-Critically-Ill-Gravida/Default.aspx29-Mar-2012The longstanding view that maternal use of sedatives and opioids were safe in breastfeeding changed dramatically after we published a case report of an 11-day-old healthy full-term baby who had died, without postmortem anatomical findings. The baby had a high blood morphine level, and genetic...http://www.medconnect.me/tabid/93/ct1/c11872/Perspective-Opiates-and-Sedatives-During-Breastfeeding/Default.aspx28-Mar-2012I was an art history major in college. The challenge of sorting out ancient Greek sculptures and Renaissance paintings suited my observational skills and avoided my difficulties with numbers. When it came time to practice medicine, it was clear that I would behave more like an artist than a...http://www.medconnect.me/tabid/93/ct1/c11873/Commentary-Enough-Is-Enough-/Default.aspx28-Mar-2012NEW YORK (EGMN)– Patients with gout who took colchicine had less than one-half the risk of having a myocardial infarction that was seen in patients who were untreated for their gout. But this protective effect was not seen for patients taking allopurinol, Dr. Michael Pillinger, a coauthor of the...http://www.medconnect.me/tabid/93/ct1/c11874/Colchicine-Dramatically-Cuts-MI-Risk-in-Gout/Default.aspx26-Mar-2012CHICAGO (EGMN)–Patients with high platelet reactivity on standard-dose clopidogrel in conjunction with a drug-eluting stent for stable coronary disease obtain markedly greater platelet inhibition by switching to prasugrel at 10 mg/day than by doubling the clopidogrel dose to 150 mg/day, according...http://www.medconnect.me/tabid/93/ct1/c11875/Prasugrel-Bests-Double-Dose-Clopidogrel-in-Clopidogrel-Nonresponders/Default.aspx25-Mar-2012CHICAGO (EGMN) –Frailty and three common chronic health conditions place patients at greater risk of late mortality following transcatheter aortic valve replacement, according to extended follow-up of 339 patients in the Multicenter Canadian Experience study. The overall survival rate was 57%...http://www.medconnect.me/tabid/93/ct1/c11876/Four-Common-Comorbidities-Hike-Risk-of-Late-Post-TAVI-Death/Default.aspx24-Mar-2012DENVER (EGMN) –A structured approach to giving pain medications to agitated nursing home residents with moderate to severe dementia – regardless of their pain scores – significantly reduced their agitation and aggression in a randomized trial. “The assumption is that their agitation was related...http://www.medconnect.me/tabid/93/ct1/c11878/Pain-Medications-Relieve-Agitation-in-Demented-Patients/Default.aspx23-Mar-2012A recent report from the Agency for Healthcare Research and Quality (AHRQ), a U.S. governmental entity in the Department of Health and Human Services, concluded that there are “no significant differences in the risk of maintaining seizure freedom” or safety between old and new antiepileptic drugs....http://www.medconnect.me/tabid/93/ct1/c11879/Value-of-Epilepsy-Drug-Review-Questioned/Default.aspx19-Mar-2012